The Ward lab at UC Santa Cruz
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      • 2017 Worm meeting
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    • pha-1 co-conversion >
      • Strain maintenance
      • cku-80 RNAi
      • Construct and oligo design
      • Generation of PU6::sgRNA templates by PCR fusion
      • Injections
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Research Overview

The Ward lab is interested in the mechanisms of biological timers, how their outputs coordinate cell physiology, and how they can be co-opted into new biological processes.  We use the nematode C. elegans as a model organism to approach these problems. We use a combination of genetics, molecular biology, microscopy, in vitro biochemistry, and genomics to understand how a large-scale gene expression oscillator works to control rhythmic skin generation. Our study of one component of this oscillator (NHR-23) has brought us into the germline, where we study how it coordinates spermatogenesis. NHR-23 oscillates in the soma, yet is constitutively expressed in the testes. Interestingly,  many mammalian rhythm regulators do the same, but this phenomenon is poorly understood. We also build tools to aid our research and aim to distribute these to the community. Our work is funded by an R01 grant from the NIH/National Institute of General Medical Sciences and a National Science Foundation CAREER award.


Molting
Spermatogenesis
tool development
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  • Home
  • Research
    • Molting
    • Spermatogenesis
    • Tool development
  • People
    • Current Ward Lab Members
    • Former lab members
    • Positions
  • Publications
    • Peer Reviewed Publications
    • Preprints
    • K99 grant writing
    • Our neglected blog
    • Meeting slides >
      • 2017 Worm meeting
      • 2019 Worm meeting
  • Methods & protocols
    • Biochemistry
    • C. elegans
    • Molecular biology
    • pha-1 co-conversion >
      • Strain maintenance
      • cku-80 RNAi
      • Construct and oligo design
      • Generation of PU6::sgRNA templates by PCR fusion
      • Injections
      • FAQs
  • Contact us